Bipolar disorder associated with interferon-alpha treatment.
نویسندگان
چکیده
Accepted 9 July 1997 Interferon-alpha (Hoffman-La Roche Ltd, Basel, Switzerland) is a highly purified, bacterially synthesized agent with antiviral, antiproliferative and immunomodulatory properties.' Interferon-alpha has been approved for the treatment of several types of cancer (eg, leukaemia, lymphoma, renal cell carcinoma and melanoma) and of chronic hepatitis.2'4 Usually causing flu-like symptoms, interferonalpha's most serious adverse effects are those related to the central nervous system, including psychiatric side-effects."'56 Psychiatric adverse effects include anxiety, irritability, depression, psychosis and delirium"'6-9 and even suicidality.'0 We report the precipitation of bipolar disorder after interferon-alpha therapy for chronic myeloid leukaemia in a previously healthy 47year-old man. We believe that this constitutes the first report of development of bipolar disorder in association with interferon-alpha treatment.
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ورودعنوان ژورنال:
- Postgraduate medical journal
دوره 73 866 شماره
صفحات -
تاریخ انتشار 1997